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generic drug for nexium 40 mg
generic drug for nexium 40 mg

Generic Name: esomeprazole

Pill with imprint NEXIUM 40 mg is Purple, Capsule-shape and has been identified as Nexium 40 mg. It is supplied by AstraZeneca Pharmaceuticals.

Nexium is used in the treatment of gerd; barrett’s esophagus; erosive esophagitis; duodenal ulcer prophylaxis; helicobacter pylori infection and belongs to the drug class proton pump inhibitors. Risk cannot be ruled out during pregnancy. Nexium 40 mg is not a controlled substance under the Controlled Substances Act (CSA).

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Other brands: Nexium 24HR

generic drug for nexium 40 mg

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Medically reviewed by C. Fookes, BPharm Last updated on May 16, 2018.

Other names: PPIs

PPIs reduce the production of acid by the stomach. They work by irreversibly blocking an enzyme called H+/K+ ATPase which controls acid production. This enzyme is also known as the proton pump and is found in the parietal cells of the stomach wall.

PPIs treat conditions that are caused by either an overproduction of stomach acid or exacerbated by stomach acid. Taking a PPI once a day inhibits around 70% of proton pumps, so a small amount of acid is still available for food digestion.

PPIs may be used for the treatment of:

generic drug for nexium 40 mg

All PPIs work in the same way, by inhibiting the proton pump. However, there are differences in their propensity for drug interactions, and in the way they bind to the proton pump. This can affect how long they last for.

All the PPIs available in the U.S. are metabolized in the liver by certain liver enzymes (mainly CYP2C19 and 3A4). There is a lot of individual variation in the way these liver enzymes work, and experts have identified three categories of people; extensive metabolizers (homEM), poor metabolizers (PM), and people that sit somewhere in between (hetM).

Approximately 3% of Caucasians and 15-20% of Asians are PM. PM take longer to excrete the drug and therefore their response to PPIs is increased several fold. For example, the pH of gastric acid is around 6 in PM after PPIs compared to around 3-4 in extensive metabolizers (where 1 is the most acidic pH). Metabolism is also affected in people of an older age and in those with liver disease. Esomeprazole is the only PPI that is well tolerated by people with liver disease. The extent somebody is able to metabolize a PPI can also affect their risk of drug interactions. 

When taken at the recommended dosage for the recommended duration of time, PPIs are considered safe. However, they have been associated with several serious adverse effects including:

In addition, there is a risk that the use of PPIs may mask the symptoms of gastric cancer. All patients with a suboptimal response to PPIs or whose symptoms recur following PPI withdrawal should have additional diagnostic testing, and an endoscopy should be considered in older people before treatment initiation.

Patients should only take PPIs as directed by their doctor or according to the instructions on the packet if bought over the counter.

PPIs are generally well tolerated. The more common side effects reported with their use include:

For a complete list of side effects, please refer to the individual drug monographs.

View by: Brand | Generic

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Medical conditions associated with proton pump inhibitors:

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See also: Generic Nexium IV

Nexium is a brand name of esomeprazole, approved by the FDA in the following formulation(s):

A generic version of Nexium has been approved by the FDA. However, this does not mean that the product will necessarily be commercially available – possibly because of drug patents and/or drug exclusivity. The following products are equivalent to Nexium and have been approved by the FDA:

Note: No generic formulation of the following product is available.

Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Nexium. These medications may be counterfeit and potentially unsafe. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy. Ask your health care provider for advice if you are unsure about the online purchase of any medication.

generic drug for nexium 40 mg

See also: Generic Drug FAQs.

Patents are granted by the U.S. Patent and Trademark Office at any time during a drug’s development and may include a wide range of claims.

The present invention describes an improved process for the preparation, isolation, and purification of the anti-ulcer agent omeprazole whereby the sulfide precursor pyrmetazole is reacted subsurfacely with exactly one molar equivalent of meta-chloroperoxybenzoic acid in methylene chloride or toluene solution; residual organic solvent is removed from the aqueous layer by vacuum distillation; crude product is obtained by reactive crystallization with an alkyl formate and seeding; and pure product is isolated by recrystallization in methanol-water containing aqueous NaOH by subsurface addition of aqueous acetic acid to pH 9.0, seeding, filtration, washing, and drying. Compositions of omeprazole containing no chromatographically detectable levels of residual non-alcoholic organic reaction solvent are also described.

Patent expiration dates:

The present invention describes an improved process for the preparation, isolation, and purification of the anti-ulcer agent omeprazole whereby the sulfide precursor pyrmetazole is reacted subsurfacely with exactly one molar equivalent of meta-chloroperoxybenzoic acid in methylene chloride or toluene solution; residual organic solvent is removed from the aqueous layer by vacuum distillation; crude product is obtained by reactive crystallization with an alkyl formate and seeding; and pure product is isolated by recrystallization in methanol-water containing aqueous NaOH by subsurface addition of aqueous acetic acid to pH 9.0, seeding, filtration, washing, and drying. Compositions of omeprazole containing no chromatographically detectable levels of residual non-alcoholic organic reaction solvent are also described.

Patent expiration dates:

The present invention describes an improved process for the preparation, isolation, and purification of the anti-ulcer agent omeprazole whereby the sulfide precursor pyrmetazole is reacted subsurfacely with exactly one molar equivalent of meta-chloroperoxybenzoic acid in a chlorinated aliphatic hydrocarbon or aromatic hydrocarbon solvent, such as methylene chloride or toluene; residual organic solvent is removed from the aqueous layer by vacuum distillation; crude product is obtained by reactive crystallization with an alkyl formate or formic acid solution and seeding; and pure product is isolated by recrystallization in methanol-water containing aqueous NaOH by subsurface addition of aqueous acetic acid to pH 9.0, seeding, filtration, washing, and drying. Omeprazole and compositions of omeprazole containing no chromatographically detectable levels of residual non-alcoholic organic reaction solvent and diminished levels of alcoholic solvent are also described.

Patent expiration dates:

An enteric coated oral pharmaceutical formulation comprising as active ingredient a compound selected from the group of omeprazole, an alkaline salt of omeprazole, one of the single enantiomers of omeprazole and an alkaline salt of one of the single enantiomers of omeprazole, wherein the formulation comprises a core material that comprises the active ingredient and optionally an alkaline reacting compound, the active ingredient is in admixture with a pharmaceutically acceptable excipient, such as for instance a binding agent, and on said core material a separating layer and an enteric coating layer. A hydroxypropyl cellulose (HPC) with a specific cloud point is used in the manufacture of the claimed pharmaceutical formulations. Furthermore, the application describes the processes for their preparation and the use of the claimed formulations in medicine.

Patent expiration dates:

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Other brands: Nexium 24HR

Latest: Heartburn Drugs Might Bring Allergy Woes


Nexium reviews

Xenleta (lefamulin) is a first-in-class, semi-synthetic pleuromutilin…

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Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 1 Aug 2019), Cerner Multum™ (updated 1 Aug 2019), Wolters Kluwer™ (updated 31 July 2019) and others.

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Important Information About NEXIUM

Turns Off Acid Pumps

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generic drug for nexium 40 mg

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NEXIUM is a proton pump inhibitor (PPI). There are other branded PPIs available and only some of them have generic equivalents.

It is important to know that not all medications, branded or generics, work the same for all patients.

When your doctor prescribes a medication, it is because it has been determined it is the right one for you.

If your doctor prescribes NEXIUM make sure that’s what your pharmacist gives you. NEXIUM 40 mg is only available with a prescription.

 

LEARN MORE about NEXIUM Direct, a program offering patient services through AstraZeneca’s pharmacy partner, including delivery of prescription NEXIUM 40 mg* by mail to your door

*Both NEXIUM 20 mg and 40 mg strengths are available through this program

 

How AcidReflux Occurs

How AcidReflux CanCause Damage

How NEXIUM Can RelieveHeartburn

Please see full Prescribing Information.

for treating and healing

is easier when you’re prepared

NEXIUM is prescribed to treat the symptoms of acid reflux disease, which typically include persistent heartburn on 2 or more days per week, despite treatment and change of diet.

For many people, NEXIUM is also prescribed to heal damage to the esophagus called erosive esophagitis. This damage may be caused over time from stomach acid wearing away the lining of the esophagus. Only a doctor can diagnose this condition. With NEXIUM, most erosions heal in 4 to 8 weeks. Your results with NEXIUM may vary.

You may report side effects related to AstraZeneca products by clicking here.

The information on this Web site should not take the place of talking with your doctor or health care professional. If you have any questions about your condition, or if you would like more information about NEXIUM, talk to your doctor or pharmacist. Only you and your health care professional can decide if NEXIUM is right for you.

If you have any questions or would like additional information, please contact AstraZeneca at 1-800-236-9933, Monday through Friday, 8 AM to 6 PM ET, excluding holidays.

© AstraZeneca

No links configured

This product information is intended for US consumers only.

NEXIUM and the color purple as applied to the capsule are registered trademarks of the AstraZeneca group of companies.

©2018 AstraZeneca. All rights reserved. 1958011-3194104; US-21395 Last Updated 8/18

It will help does not occur use this as long as hours nexium pill color.

Still, Bosler adds, deaths have nexium pill color reported that more likely to from Publisher.

Copyright © 2016 FASBA e.V.. Powered by
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Esomeprazole, sold under the brand names Nexium among others,[1] is a medication which reduces stomach acid.[3] It is used to treat gastroesophageal reflux disease, peptic ulcer disease, and Zollinger–Ellison syndrome.[3][4] Effectiveness is similar to other proton pump inhibitors (PPIs).[5] It is taken by mouth or injection into a vein.[3]

Common side effects include headache, constipation, dry mouth, and abdominal pain.[3] Serious side effects may include angioedema, Clostridium difficile infection, and pneumonia.[3] Use in pregnancy appear to be safe while safety during breastfeeding is unclear.[6] Esomeprazole is the (S)-(−)-isomer of omeprazole.[3] It works by blocking H+/K+-ATPase in the parietal cells of the stomach.[3]

It was patented in 1993 and approved for medical use in 2000.[7] It is available as a generic medication and sold over the counter in a number of countries.[8][4] A month supply in the United Kingdom costs the NHS about £3 per month as of 2019.[4] In the United States the wholesale cost of this amount is about 10 USD.[9] In 2016 it was the 69th most prescribed medication in the United States with more than 11 million prescriptions.[10]

The primary uses of esomeprazole are gastroesophageal reflux disease, treatment and maintenance of erosive esophagitis, treatment of duodenal ulcers caused by H. pylori, prevention of gastric ulcers in those on chronic NSAID therapy, and treatment of gastrointestinal ulcers associated with Crohn’s disease.[11][12]

generic drug for nexium 40 mg

Gastroesophageal reflux disease (GERD) is a condition in which the digestive acid in the stomach comes in contact with the esophagus. The irritation caused by this disorder is known as heartburn. Long-term contact between gastric acids and the esophagus can cause permanent damage to the esophagus. Esomeprazole reduces the production of digestive acids, thus minimizing their effect on the esophagus.

Esomeprazole is combined with the antibiotics clarithromycin and amoxicillin (or metronidazole instead of amoxicillin in penicillin-hypersensitive patients) in a 10-day eradication triple therapy for Helicobacter pylori. Infection by H. pylori is a causative factor in the majority of peptic and duodenal ulcers.

A 2006 meta analysis concluded that compared to other proton pump inhibitors, esomeprazole confers a modest overall benefit in esophageal healing and symptom relief. When broken down by disease severity, the benefit of esomeprazole relative to other proton pump inhibitors was negligible in people with mild disease (number needed to treat 50), but appeared more in those with severe disease (number needed to treat 8).[13] A second meta analysis also found increases in erosive esophageal healing (>95% healing rate) when compared to standardized doses in broadly selected patient populations.[14] A 2017 study found esomeprazole to be among a number of effective doses of PPIs.[15]

Common side effects include headache, diarrhea, nausea, flatulence, decreased appetite, constipation, dry mouth, and abdominal pain. More severe side effects are severe allergic reactions, chest pain, dark urine, fast heartbeat, fever, paresthesia, persistent sore throat, severe stomach pain, unusual bruising or bleeding, unusual tiredness, and yellowing of the eyes or skin.[16]

Proton pump inhibitors may be associated with a greater risk of hip fractures[17] and Clostridium difficile-associated diarrhoea.[18] Patients are frequently administered the drugs in intensive care as a protective measure against ulcers, but this use is also associated with a 30% increase in occurrence of pneumonia.[19]

Long-term use of PPIs in patients treated for Helicobacter pylori has been shown to dramatically increase the risk of gastric cancer.[20]

Esomeprazole is a competitive inhibitor of the enzyme CYP2C19, and may therefore interact with drugs that depend on it for metabolism, such as diazepam and warfarin; the concentrations of these drugs may increase if they are used concomitantly with esomeprazole.[21] Conversely, clopidogrel (Plavix) is an inactive prodrug that partially depends on CYP2C19 for conversion to its active form; inhibition of CYP2C19 blocks the activation of clopidogrel, thus reducing its effects.[22][23]

Drugs that depend on stomach pH for absorption may interact with omeprazole; drugs that depend on an acidic environment (such as ketoconazole or atazanavir) will be poorly absorbed, whereas drugs that are broken down in acidic environments (such as erythromycin) will be absorbed to a greater extent than normal.[21]

Single 20 to 40 mg oral doses generally give rise to peak plasma esomeprazole concentrations of 0.5-1.0 mg/l within 1–4 hours, but after several days of once-daily administration, these levels may increase by about 50%. A 30-minute intravenous infusion of a similar dose usually produces peak plasma levels on the order of 1–3 mg/l. The drug is rapidly cleared from the body, largely by urinary excretion of pharmacologically inactive metabolites such as 5-hydroxymethylesomeprazole and 5-carboxyesomeprazole. Esomeprazole and its metabolites are analytically indistinguishable from omeprazole and the corresponding omeprazole metabolites unless chiral techniques are employed.[24]

Esomeprazole is available as delayed-release capsules in the United States or as delayed-release tablets in Australia, the United Kingdom, and Canada (containing esomeprazole magnesium) in strengths of 20 and 40 mg, as delayed-release capsules in the United States (containing esomeprazole strontium) in a 49.3 mg strength (delivering the equivalent of 40 mg of esomeprazole,[25] and as esomeprazole sodium for intravenous injection/infusion. Oral esomeprazole preparations are enteric-coated, due to the rapid degradation of the drug in the acidic conditions of the stomach. This is achieved by formulating capsules using the multiple-unit pellet system.

The combination naproxen/esomeprazole magnesium (brand name Vimovo) is used for the prevention of gastric ulcers associated with chronic NSAID therapy. Vimovo is available in two dosage strengths: 500/20 mg and 375/20 mg. Clinical trials of naproxen/esomeprazole demonstrated an incidence of GI ulcer in 24% of patients on naproxen (alone) versus 7% on naproxen/esomeprazole.[26] The FDA has added warnings to the label for Vimovo concerning acute interstitial nephritis and risk of kidney problems in some patients.[27]

Esomeprazole capsules, as well as Losec/Prilosec tablets, are formulated as a “multiple-unit pellet system” (MUPS). Essentially, the capsule consists of extremely small enteric-coated granules (pellets) of the esomeprazole formulation inside an outer shell. When the capsule is immersed in an aqueous solution, as happens when the capsule reaches the stomach, water enters the capsule by osmosis. The contents swell from water absorption, causing the shell to burst, and releasing the enteric-coated granules. For most patients, the multiple-unit pellet system is of no advantage over conventional enteric-coated preparations.[citation needed] Patients for whom the formulation is of benefit include those requiring nasogastric tube feeding and those with difficulty swallowing (dysphagia).[citation needed]

In 2010, AstraZeneca announced a co-promotion agreement with Daiichi Sankyo to distribute Nexium in Japan.[28] In September 2011, Nexium was approved for sale and was launched by Daiichi Sankyo in Japan.[29] Nexium is also sold online with a prescription via Nexium direct.[citation needed]

Between the launch of esomeprazole in 2001 and 2005, the drug netted AstraZeneca about $14.4 billion.[30]

There has been some controversy about AstraZeneca’s behaviour in creating, patenting, and marketing of the drug. Esomeprazole’s successful predecessor, omeprazole, is a mixture of two mirror-imaged molecules (esomeprazole which is the S-enantiomer, and R-omeprazole); critics said the company was trying to “evergreen” its omeprazole patent by patenting the pure esomeprazole and aggressively marketing to doctors that it is more effective than the mixture.[31]

Thomas A. Scully, head of the Centers for Medicare and Medicaid Services (CMS), also criticized AstraZeneca for their aggressive marketing of Nexium. At a conference of the American Medical Association (AMA), he said that Astra was using the new drug to overcharge consumers and insurance companies.[citation needed]

Generic versions of esomeprazole magnesium are available worldwide.[1] It is available over-the-counter under the brand name Nexium in the United States[32] and in the UK.[citation needed]

Nexium recently became much cheaper as Perrigo PLC began delivering its own over-the-counter generic version of esomeprazole magnesium earlier this month. Perrigo’s generic form of this popular and easily available heartburn medication received FDA approval on September 27; within a week, it was for sale at grocery and drug stores across the country as store brand products.

Perrigo is not the first drugmaker to attempt to cash in on Nexium’s popularity. Teva Pharmaceuticals was the first to get FDA approval for a generic version of prescription esomeprazole in January 2015. This was granted following a long legal battle with AstraZeneca, which held the original patent, and Ranbaxy, which had hoped to be the first to get their product onto pharmacy shelves when the patent expired. However, Perrigo is the first to get approval for a generic OTC version of Nexium.

The rush to produce generic esomeprazole is not surprising, given the revenues at stake. During its first five years on the market, Nexium sales brought in approximately $14 billion for AstraZeneca. When the patent expired in May 2014, AstraZeneca benefited from a bureaucratic roadblock at the FDA that delayed approval of a generic version for several months, enabling the company to squeeze out another $2.8 billion in revenue from Nexium that year. Since 2014, sales of OTC Nexium have made approximately $300 million a year for Pfizer, which has had exclusive rights to that version of the drug up until now.

Small wonder that smaller drug companies have been stampeding to get approval for their own versions. Esomeprazole’s popularity nonetheless seems odd in light of safety concerns that have come to light. In 2010, the FDA issued a warning over an association between frequent use of esomeprazole and increased risk of osteoporosis. Three years later, a safety notice was published on links to acute interstitial nephritis, an inflammation of the kidneys that can result in renal failure. Since that time, studies have made connections between esomeprazole and dementia, accelerated aging, increased risk of stroke and ulcerative colitis.

AstraZenca and six other drug companies that have marketed and manufactured proton pump inhibitors have been targeted in approximately 160 lawsuits, which were consolidated into multidistrict litigation (MDL) this past August. Plaintiffs allege that drug makers failed to warn patients and doctors of the dangers of kidney damage caused by the medication. Another MDL in which plaintiffs alleged bone injuries resulting from taking Nexium was closed three years ago when the judge ruled in favor of defendant AstraZeneca, citing an expert witness’ lack of qualification after granting the defendant’s motion to exclude her testimony.

generic drug for nexium 40 mg

AstraZeneca has wound up paying some hefty fines over the years in connection with Nexium. In 2015, the company paid out almost $28 million in penalties to the federal government to resolve allegations over deceptive marketing and physician kickbacks.

While there is little risk from the occasional use of proton pump inhibitors such as esomeprazole, it has been over-prescribed and over-utilized, often used to treat forms of heartburn for which the drug was not designed. Furthermore, PPIs such as Nexium do not offer immediate relief; according to Perrigo’s label, it can require anywhere from 24 to 96 hours for the medication to take effect.

Now that Nexium is more easily available and less expensive than ever before, it is vital for consumers to educate themselves about the numerous risks of taking the medication – and seek alternatives whenever possible.

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I am usually supportive of the pharmaceutical industry (1). People who reflexively criticize it have no idea how difficult and expensive it is to get something from the lab to the pharmacy. Also, many people think that drug companies don’t provide innovation, and do little more than manufacture something that the NIH or a university came up with. This could not be more wrong. Pharmaceutical companies have discovered and developed drugs that have had an enormous impact on human health. They do all the heavy lifting.

But, there are exceptions. For example, AstraZeneca marketed a drug that should have never been approved in the first place: Nexium. They did it solely for money—without any benefit to society— and it has sure worked out well for them. It made AstraZeneca almost $48 billion during the past decade, without any innovation or benefit to people who had previously been taking Prilosec to control their heartburn.

They didn’t deserve a penny of it. Instead, the “purple pill” marketing plan was brilliant. 

Following is the story of how the company was able to get away with this. 

generic drug for nexium 40 mg

First, whenever you see a drug name starting with “Es,” it is time to be suspicious:

Omeprazole (Prilosec)

Esomeprazole (Nexium)

Aside from the “Es” in the second compound, the names are identical, which makes perfect sense, since the two drugs are essentially the same. But there is one tiny (and usually insignificant) difference that enabled AstraZeneca to replace its Prilosec patent, which ran out in 2001, with Nexium (2).This requires a little bit of chemistry but if you are a reader here, you can probably follow along and learn about optical isomerism.

An example of an asymmetric molecule. The carbon atom is the gray sphere. Source: Chemtube3D

Any molecule that contains a carbon atom (3) that has four different substituents (atoms, groups, rings…) bound to it is, by definition, asymmetrical. In the figure above, the carbon atom (gray) is attached to four different substituents, the spheres shown in red, blue, yellow, and green. Although chemically identical—the two molecules will have the exact same properties (melting point, boiling point, solubility in water…)—they are not identical in every way.

Asymmetric molecules exist in two forms (4) called enantiomers – mirror images of each other. They have the same substituents on carbon, but it is impossible to superimpose one enantiomer on another—the acid test for identity. 

This explains the “Es” prefix.

To distinguish one enantiomer from another one is called the “R” form, the other the “S” form. The “S” is why the generic name for Nexium is Esomeprazole. It is simply Prilosec with the “R” form removed. Most asymmetric chemicals are a 50-50 mixture of R and S (6). This is called a racemate (or racemic mixture). A simple example is a 50-50 mixture of R- and S-lactic acid lactic acid:

Now we can take a look at why Nexium was a rip-off. Although instruments like a mass spectrometer or NMR cannot tell the difference between R and S, your body can. Almost inevitably, when a drug is a racemic mixture, one enantiomer will be the active species, while the other will be inactive and just going along for the ride. Thus, a 100 mg pill of a racemic mixture (Prilosec) will contain only 50 mg of active drug. But a 100 mg dose of a single enantiomer (Nexium) contains 100 mg. So, a single enantiomer will deliver twice the effective dose of the racemate.

So, did Nexium represent a $48 billion improvement over Prilosec? Not really, but there are web sites where numerous people have written that Nexium worked better than Prilosec for them. And, they are no doubt right. The dosing schedule for Prilosec shows why:

And for Nexium:

Although the dosage of the pills (above) is the same (colored circles), the people who are taking Nexium are getting twice the effective dose than those who are taking Prilosec, so it makes perfect sense that they feel better. But, instead of taking one purple pill people with heartburn, they could have taken two generic non-purple pills to get the same effect and saved $48 billion. This is innovation?

No, it is not. This was a money grab by AstraZeneca. They picked a pretty color, ran relentless commercials, and managed to convince patients and doctors that the “purple pill” was somehow better. Except it isn’t. 

Nonsense like this gives the whole industry a bad name. AstraZeneca somehow managed to convince the US Patent Office that Nexium was substantially different from Prilosec, and thus should be granted its own patent, along with 20 years of protection (7). I don’t get it, and if I’m in the patent office there is no way this gets by me. 

Purple pill, my a##.

Notes:

(1) Seriously, when I defend this chemistry or medicine people assume I must be a “shill for Big Pharma,” but the industry tossed out my sorry ass (along with tens of thousands of others) out in 2010. I defend the industry when the science is right.

(2) A patent gives a drug company the exclusive right to sell a product until the patent expires. It does not give the company permission to sell the product. This comes from the FDA. The protection (20) years starts when the patent is filed, not when it is approved. The period of exclusivity is usually around ten years.

(3) Chemicals that contain sulfur bound to three different substituents (rare) are also asymmetric (for reasons you do not want to know. Your head would explode). Prilosec/Nexium happens to be one example of this. Prilosec was a racemate (RS), and Nexium is a single enantiomer (S). 

(4) The common analogy to illustrate enantiomers is your hands. They look the same, but you cannot superimpose one hand on the other. Your hands are also mirrored images of each other. 

(5) The designation of either R or S is based on a rather complicated system of nomenclature. If I try to explain this, you will hang yourself.

(7) The strategy behind Nexium is called patent extension—a strategy to increase the amount of time during which the company that made the initial discovery has a “monopoly” on a particular drug, in this case, one that is essentially identical. 

View the discussion thread.

By Josh Bloom

Dr. Josh Bloom, the Director of Chemical and Pharmaceutical Science, comes from the world of drug discovery, where he did research for more than 20 years. The field of drug discovery involves chemistry, biochemistry, toxicology, and pharmacology – skills that he has used to write on a wide variety of topics since he joined ACSH in 2010. One of the topics he has tackled is the so-called “opioid crisis.” He is now recognized as an expert in this area and was the first journalist to write a nationally published opinion piece about the unintended consequences of a governmental crackdown on prescription pain medications (New York Post, 2013). Since that time he has published more than 20 op-eds in regional and national newspapers on different aspects of the crisis. In that same year, he testified at an FDA hearing, where he noted that fentanyl was the real danger, something that would be proven years later. At that time almost no one had heard of the drug.

He was also the first writer (2016) to study, dissect and ultimately debunk the manipulated statistics used by the CDC to justify its recommendations for opioid prescribing, which have resulted in Draconian requirements for prescribing pain medications as well as government-mandated, involuntary tapering of patients receiving opioid treatment, both of which have caused great harm and needless suffering to chronic pain patients. His 2016 article, “Six Charts Designed to Confuse You,” is the seminal work on CDC deception and has been adopted by patient advocacy groups and individuals and has been sent to governors and state legislatures.

Dr. Bloom earned his Ph.D. in organic chemistry from the University of Virginia, followed by postdoctoral training at the University of Pennsylvania. His career in drug discovery research began at Lederle Laboratories, which was acquired by Wyeth in 1994, which itself was acquired by Pfizer in 2009. During this time he participated in research in a number of therapeutic areas, including diabetes and obesity, antibiotics, HIV/AIDS, hepatitis C, and oncology. His group discovered the novel antibiotic Tygacil®, which was approved by the FDA for use against resistant bacterial infections in 2005. He is the author of 25 patents, and 35 academic papers, including a chapter on new therapies for hepatitis C in Burger’s Medicinal Chemistry, Drug Discovery and Development, 7th Edition (Wiley, 2010), and has given numerous invited lectures about how the pharmaceutical industry really works.

Dr. Bloom joined the American Council on Science and Health in 2010 as ACSH’s Director of Chemical and Pharmaceutical Sciences, and has since published more than 60 op-eds in numerous periodicals, including The Wall Street Journal, Forbes, New Scientist, The New York Post, National Review Online, The Boston Herald, and The Chicago Tribune, and given numerous radio and television interview on topics related to drugs and chemicals. In 2014, Dr. Bloom was invited to become a featured writer for the site Science 2.0, where he wrote more 75 pieces on a broad range of topics.

“Big Fears Little Risks” is a documentary, but unlike most of what you see on places like Netflix, it is pro-science, and not scaremongering trace chemicals, food, or the modern world. We instead are going to take back the discourse from trial lawyers and the trade groups they use to profit from fear.

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Phone: 212.362.7044

The American Council on Science and Health is a research and education organization operating under Section 501(c)(3) of the Internal Revenue Code. Contributions are fully tax-deductible. ACSH does not accept government grants or contracts, nor do we have an endowment. We raise our funds each year primarily from individuals and foundations.

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